ea0021p21 | Bone | SFEBES2009
Loh Nellie Y
, Dimke Henrik
, Bentley Liz
, Tammaro Paolo
, Hough Tertius
, Cox Roger D
, Brown Steve D M
, Ashcroft Frances M
, Hoenderop Joost
, Bindels Rene
, Thakker Rajesh V
Transient receptor potential cation channel, subfamily Vanilloid, member 5 (TRPV5) is a member of the TRP superfamily. TRPV5, which functions as a tetramer, is localized to apical membranes of distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, and is involved in vitamin D-regulated calcium reabsorption. Mice with a targeted deletion of Trpv5 (Trpv5−/−) develop severe hypercalciuria, compensatory hyperabsorption of dietary ...